2022-02-24
Glutathione is widely found in animals and plants and plays an important role in organisms. In baker's yeast, wheat germ, and high content of liver, up to 100 ~ 1000 mg / 100 g, in the human blood contains 26 ~ 34 mg / 100 g, chicken blood contains 58-73 mg / 100 g, pig blood contains 10 ~ 15 mg / 100 g, and higher content in tomato, pineapple, cucumber (12 ~ 33 mg / 100 g), and in the sweet potato, mungbean sprout, onion, mushroom content is low (0.06 ~ 0.7 mg / 100 g).
Excessive free radicals produced by the metabolism of new and old generations of the body will damage biofilm, invade macromolecules of life, accelerate the aging of the body, and induce the generation of tumors or atherosclerosis. Glutathione plays an important role in the biochemical defense system in human body and has many physiological functions. Its main physiological function is to scavenge free radicals in the body, which act as an important antioxidant in the body and protect the sulfhydryl group in many proteins and enzymes. The structure of GSH contains an active sulfhydryl -SH, which is easily oxidized and dehydrogenated. This specific structure makes GSH a major free radical scavenging agent in the body. For example, when a small amount of H2O2 is generated in cells, GSH reduces H2O2 to H2O under the action of glutathione peroxidase, and GSSG itself is oxidized to GSSG. GSSG, under the action of glutathione reductase existing in liver and red blood cells, receives H to be reduced to GSH, so that free radical scavenging reactions in the body can continue.
Glutathione can not only eliminate free radicals in human body, but also improve human immunity. Glutathione is a healthy, anti-aging drug that works better on aging cells than it does in younger people.
Glutathione also protects hemoglobin from oxidation by hydrogen peroxide, free radicals, and so on, allowing it to continue to transport oxygen properly. Under the action of oxidizing agent such as hydrogen peroxide, some hemoglobin in red blood cells is oxidized to ferric iron, which makes hemoglobin change to methemoglobin, and thus loses its oxygen-carrying capacity. Reduced glutathione can either bind directly to oxidants such as hydrogen peroxide to produce water and oxidized glutathione, or reduce methemoglobin to hemoglobin. Glutathione is abundant in human red blood cells, which plays an important role in the reduction of the sulfhydryl group, which protects the proteins on the red blood cell membrane and prevents hemolysis.
Glutathione protects the -SH group in the enzyme molecule, which is beneficial to the activity of the enzyme, and can restore the activity of the -SH group in the damaged enzyme molecule, so as to restore the activity of the enzyme. Glutathione also inhibits fatty liver disease caused by ethanol.
Glutathione has a strong protective effect against leukopenia caused by radiation and radiotherapeutic agents. Glutathione can be combined with toxic compounds, heavy metal ions or carcinogens that enter the human body, and promote its excretion to neutralize and detoxify.
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